“THC has a high reputation,” opened Bryan W. Brickner, “and
today’s science advises we note its ultralow nature as well.”
In Homeostasis: Publius’ (Ultralow) THC Political Cannabinoid Science, new on the Bryan William
Brickner Blog, four 2014 PubMed articles are highlighted on cannabinoid system
(CS) modulation and homeostasis ~ with one reporting THC effectiveness at doses three to four times lower than conventional
use. The Publius CS update includes: hippocampus inhibition and
excitation, pain relief from a Chinese herb (thunder God vine), GABA pain
dis-inhibition, and brain protection from a single ultralow dose of
tetrahydrocannabinol (THC).
Brickner,
part of Publius and publisher of The Cannabis Papers: A citizen’s guide to
cannabinoids (2011), noted the CS political science nature of the THC news. In
the PubMed article, Ultralow doses of cannabinoid drugs protect the mouse brain
from inflammation-induced cognitive damage, it’s reported how an extremely low dose of THC shields the
brain from harmful inflammation.
“The CS is not ultra-slow,” explained
Brickner, “as it has to work fast. In this case, lab mice were injected with a
toxin to cause inflammation; some mice were treated with ultralow doses of THC before
and after the toxin ~ and others were not. The toxin caused long-lasting
cognitive deficits in the non-THC mice; the THC mice showed no deficits and
were protected (shielded) by their CS from the toxin.”
“Fast-acting CS,” Brickner continued, “and the
shielding effects were lasting as well; the THC mice showed elevated
prostaglandin production in the hippocampus and the mice pre-treated with THC
showed even higher (good) numbers.”
“The CS acts as a shield,” closed Brickner,
“protecting via even ultralow doses ~ doses lacking any negative (too high)
quality: reputations do change and our notions of what cannabinoids can do ~
that keeps evolving.”
Next
Homeostasis: Publius’ Sleep Political Cannabinoid Science, Tuesday 30 September
on the BWB Blog.
Brickner has a 1997 political
science doctorate from Purdue University and is the author of several political
theory books, to include: The Promise Keepers (1999), Article the first (2006),
and The Book of the Is (2013). The Bryan William Brickner Blog is an
ongoing resource for the political science of constitutions and the biological
science of receptors.
The Cannabis Papers is available online and for free by
download.
