The Pirates of the Caribbean actor is being lined up to appear with Babybird next month when they make their comeback at a small London venue.
Johnny, 46, has already played a large part in the You’re Gorgeous hitmakers return, by directing the video to the first single from their new album Ex-Maniac.
He was pictured on the set of the video with British actor Stephen Graham - who he starred alongside in Public Enemies - in September.
Babybird have previously revealed Johnny was instrumental in getting the album made, after he introduced frontman Stephen Jones to some of his music producer friends.
A spokesperson for the group said: "Grammy nominated producers Bruce Witkin and Ryan Dorn were introduced to Jones by long-time Babybird fan Johnny Depp, who also makes a cameo appearance on the new recording."
Johnny is no stranger to the music world.
He played slide guitar on Oasis song Fade In-Out, which featured on the bands third album Be Here Now, and has appeared on British TV with Irish group The Pogues.
Babybird are scheduled to make their live return on November 12 at the Hoxton Bar and Kitchen in London.
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