The Get On Your Boots rockers will play in front of Berlin’s iconic Brandenburg Gate as part of the MTV European Music Awards (EMAs) on November 5, as a prelude to the city’s Fall of the Wall celebrations.
The group’s manager, Paul McGuinness, said: "It'll be an exciting spot to be in, 20 years almost to the day since the wall came down."
A source added to Britain’s Daily Mirror newspaper: "They're expecting tens of thousands of people to turn up.
"They've played some interesting places in the past but this'll certainly be the most ambitious - and most poignant - one to date."
Parts of the set will be beamed live into the EMAs which take place in the city on the same day.
Brandenburg Gate is one of the most recognisable symbols of Berlin, and was built as one of the main gates into the city when it was part of Prussia, and was completed in 1791.
Erected in 1961, the Berlin Wall divided the city and country and became a symbol of the separation between the Soviet controlled German Democratic Republic and Allied Western Germany.
The wall was eventually torn down in November 1989.
Fans who want to watch U2 perform the historic concert can apply for tickets from U2.com or their local MTV website.
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