Researchers may have discovered why certain antipsychotic medications, such as those used to treat schizophrenia, lead to extreme weight gain. A study published in the Proceedings of the National Academy of Sciences suggests that these drugs increase the activity of the enzyme AMPK in the parts of the brain that regulate eating behavior.
Patients taking the antipsychotic drugs olanzapine (sold under the brand name Zyprexa by Eli Lilly and Co.) and clozapine (sold as Clorazil by Novartis AG) have been known to gain so much weight that they are placed at increased risk for obesity-related disorders such as diabetes and cardiovascular disease.
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Antipsychotic drugs cause rapid weight gain, abnormal eating behavior
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