News / Health & Wellness
Alzheimer’s, Cancer and Homeostatic Cannabinoid Science ~ New Publius on the Bryan William Brickner Blog
Goaltending Alzheimer's and Cancer
June’s
cannabinoid science roundup on the Bryan William Brickner Blog highlights two
game-changing articles from the National Institutes of Health (PubMed). Publius
of The Cannabis Papers: A citizen’s guide to cannabinoids (2011) provides the voice
and “Yes We Can” expectations for this month’s topic: homeostasis, the
cannabinoid system (CS) and preventing Alzheimer’s disease and carcinogenesis.
In Alzheimer’s, Cancer and Homeostatic Cannabinoid Science, publisher Bryan W. Brickner
spotlights two June 2014 research articles from PubMed.
First,
how our CS modulates cognitive decline
in Alzheimer’s disease: β-Amyloid
Inhibits E-S Potentiation through Suppression of Cannabinoid Receptor
1-Dependent Synaptic Disinhibition. Second, unveiling evidence of a previously
unknown CS signaling platform ~ CB2-GPR55 receptor heteromers: Targeting CB2-GPR55 Receptor Heteromers
Modulates Cancer Cell Signaling.
“Both
this month offer insight,” Brickner noted: “the Alzheimer’s news involves the synaptic plasticity of hippocampal
cells. The science notes how the CS signals to stop firing and the brain keeps
firing: they refer to it as a ‘reduction of endocannabinoid-mediated
peritetanic disinhibition.’”
“The CS heteromer evidence enlightens as
well,” continued Brickner: “a heteromer consists of different biologic parts ~
two of our receptors in this case ~ CB2 and GPR55. It’s the idea two can do
more than one: the abstract notes the news will help clarify CS intervention in oncology.”
“Game-changing
CS news,” closed Brickner, “helps all of us.”
Brickner has a 1997 political
science doctorate from Purdue University and is the author of several political
theory books, to include The Promise Keepers: Politics and Promises (1999) and
The Book of the Is: A book on bridges (2013). The Bryan William Brickner Blog is an ongoing resource for the political science of constitutions and the
biological science of receptors.
Next
time: A Homeostatic World Cup of Cannabinoids ~ Fielders Edition, Monday July 7th,
on the BWB Blog.
