“THC has a high reputation,” opened Bryan W. Brickner, “and today’s science advises we note its ultralow nature as well.”
In Homeostasis: Publius’ (Ultralow) THC Political Cannabinoid Science, new on the Bryan William Brickner Blog, four 2014 PubMed articles are highlighted on cannabinoid system (CS) modulation and homeostasis ~ with one reporting THC effectiveness at doses three to four times lower than conventional use. The Publius CS update includes: hippocampus inhibition and excitation, pain relief from a Chinese herb (thunder God vine), GABA pain dis-inhibition, and brain protection from a single ultralow dose of tetrahydrocannabinol (THC).
Brickner, part of Publius and publisher of The Cannabis Papers: A citizen’s guide to cannabinoids (2011), noted the CS political science nature of the THC news. In the PubMed article, Ultralow doses of cannabinoid drugs protect the mouse brain from inflammation-induced cognitive damage, it’s reported how an extremely low dose of THC shields the brain from harmful inflammation.
“The CS is not ultra-slow,” explained Brickner, “as it has to work fast. In this case, lab mice were injected with a toxin to cause inflammation; some mice were treated with ultralow doses of THC before and after the toxin ~ and others were not. The toxin caused long-lasting cognitive deficits in the non-THC mice; the THC mice showed no deficits and were protected (shielded) by their CS from the toxin.”
“Fast-acting CS,” Brickner continued, “and the shielding effects were lasting as well; the THC mice showed elevated prostaglandin production in the hippocampus and the mice pre-treated with THC showed even higher (good) numbers.”
“The CS acts as a shield,” closed Brickner, “protecting via even ultralow doses ~ doses lacking any negative (too high) quality: reputations do change and our notions of what cannabinoids can do ~ that keeps evolving.”
Next Homeostasis: Publius’ Sleep Political Cannabinoid Science, Tuesday 30 September on the BWB Blog.
Brickner has a 1997 political science doctorate from Purdue University and is the author of several political theory books, to include: The Promise Keepers (1999), Article the first (2006), and The Book of the Is (2013). The Bryan William Brickner Blog is an ongoing resource for the political science of constitutions and the biological science of receptors.
The Cannabis Papers is available online and for free by download.