“Like
Wilt Chamberlain,” opened Bryan W. Brickner, “who altered the rules of college
basketball because of his contributions (talent and skill), look for bivalency
and heteronomy to do the same to cannabinoid system science.”
In Homeostasis 2015: Publius’ Cannabinoid Science Champions ~
New on the Bryan William Brickner Blog, bivalency (it doubles) and heteronomy
(not autonomous) are spotlighted for their contributions to future knowledge. The
Publius post focuses on four 2014 PubMed articles discussing: heteromerization
and CB2, unexpected (intrinsic) bivalent CS properties, and two on Orexin,
involved in arousal, wakefulness and appetite, and CB1 heterodimers and
heteromeric signaling complexes.
“Bivalency and heteronomy are Publius’ 2014 cannabinoid
science champions,” offered Brickner, publisher of The Cannabis Papers and part
of the pen name Publius; “both are CS homeostatic processes within the human
body that work without notice or acclaim. Forward looking to 2015 and beyond,
bivalency and heteronomy are cannabinoid science players with a high-knowledge
upside.”
“One example,”
Brickner noted, “is from the research on unexpected intrinsic bivalent CS
properties; the researchers found small changes in bivalent cannabinoids altered
the efficacy at the receptors by turning agonists into antagonists and inverse
agonists, which suggests the CS can change a cannabinoid into the cannabinoid
it needs.”
“The
game is life,” closed Bryan W. Brickner, “and this year’s homeostatic cannabinoid
champions, honored for their contributions to future knowledge, are game-changers
like Chamberlain: bivalency and heteronomy.”
Announcement:
In January, look for Ew Publishing’s first booklet of 2015, Bryan W. Brickner’s
Shivitti: A Review of Ka-Tzetnik 135633’s
Vision. The heal Auschwitz nightmares via serotonin booklet will be
available by (or before) 25 January 2015.
Brickner has a 1997 political
science doctorate from Purdue University and is the author of several political
theory books, to include Article the first of the Bill of Rights (2006) and The
Book of the Is (2013); he also writes political fiction, such as the novella
thereafter (2013). The Bryan William Brickner Blog is an ongoing
resource for the political science of constitutions and the biological science
of receptors.
The
Cannabis Papers is available at online retailers and for free by download.