On a day to celebrate his 3,000th career hit, which included a 45-minute pregame ceremony and Hall of Fame presentation, Biggio called two shots: his own in the fifth inning and Lance Berkman's in the eighth.
The latter broke open a tie game, sparking the Astros to a four-run eighth inning and leading the way to a 6-4 Astros victory in the finale of a crucial three-game series with the division-leading Brewers on Sunday.
Ty Wigginton hit his first home run since joining the Astros off Vargas in the sixth, tying the game at 2.
It remained that way until Berkman strode to the plate in the eighth and hammered the first pitch from reliever Carlos Villanueva to deep right, sending it 397 feet to put the Astros in front for good.
Luke Scott and Jason Lane drew walks, and Brad Ausmus drilled an RBI double down the left-field line, scoring Scott.
But after blowing a save on Saturday night, Brad Lidge came out of the bullpen and quickly put that outing behind him, retiring Kevin Mench on a popup to right to end the game and secure his eighth save in the past month.
The Astros are now 9 1/2 games back of the National League Central-leading Brewers.
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