An article has been publicized for Provectus Pharmaceuticals in the current issue of the peer-reviewed journal, Melanoma Research (20(1):48-51, February 2010). The Title of the article is “A novel treatment for metastatic melanoma with intralesional rose bengal and radiotherapy: a case series," authored by Dr. Matthew C. Foote, Dr. Bryan H. Burmeister, Janine Thomas, and Dr. B. Mark Smithers.
Craig Dees, Ph.D., President and CEO of Provectus said, “Each of the patients cited in this article were part of the Phase 2 clinical study prior to subsequent radiation therapy, and had aggressive cases of metastatic melanoma. Because the Phase 2 study protocol limited the investigator’s dosing options, Dr. Smithers and his team were not able to match the allowed dosing regimen to the natural disease course for these patients. Six to 12 weeks after receiving their final PV-10 dose, the patients received supplemental radiotherapy that led to the remarkable responses noted in the article. Dr. Smithers is now part of our compassionate use program for PV-10 which allows far more flexibility in dosing, and we look forward to assessing results from this program and their implications for optimizing how PV-10 is administered to metastatic tumors. We also anticipate additional studies to confirm these initial observations using PV-10 in conjunction with radiotherapy.”
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About Provectus Pharmaceuticals, Inc.
Provectus Pharmaceuticals specializes in developing oncology and dermatology therapies. Its lead oncology agent, PV-10, is designed to selectively target and destroy cancer cells without harming surrounding healthy tissue, significantly reducing the potential for systemic side effects. Its oncology focus is on melanoma, breast cancer and metastatic liver cancer. The Company has received orphan drug designation from the FDA for its melanoma indication. Its lead dermatological drug, PH-10, also targets abnormal or diseased cells, with the current focus on psoriasis and atopic dermatitis. Provectus has recently completed enrollment in three of its Phase 2 trials -- PV-10 as a therapy for metastatic melanoma, and PH-10 as a topical treatment for atopic dermatitis and for psoriasis. It has also recently initiated a Phase 1 trial for PV-10 for liver cancer.
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