State police say the accident involved a tractor-trailer and a pickup truck that burst into flames after the crash.
The wreck occurred about 6:20 a.m. between the Philadelphia and Willow Grove interchanges.
Several people were injured, and the turnpike is likely to stay closed most of the morning as the accident is investigated and the scene is cleared of the vehicles and a fuel spill.
Part of the concrete barrier in the center of the highway was torn out in the crash.
Both eastbound and westbound traffic has been backed up for miles.
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