Marina Biotech, Inc. (NASDAQ:MRNA) reached up 20.87% in morning trading to $.278 with 4M shares traded. Marina Biotech is a biotechnology company focused on the development and commercialization of therapeutic products based on RNA interference (RNAi). They are building multiple cutting-edge drug discovery and development platforms based on the premise that no single RNAi technology or delivery approach can be broadly applied to the treatment of all human diseases. Marina Biotech, Inc. (NASDAQ:MRNA - News) reported data demonstrating increased hybridization affinity and activity with the Company's proprietary Conformationally Restricted Nucleotide (CRN) technology. When substituted into an oligonucleotide complementary to miR-21, the melting temperature (Tm) was increased significantly; resulting in > 90% inhibition compared to 30% inhibition for a matched all-DNA version. MicroRNA-21 has established roles as an oncomiR in cancer and in proliferative conditions such as cardiac disease. Effective in vivo inhibition of miR-21 is expected to lead to increased expression of known miR-21 target genes. The inhibition of miR-21 and resulting increased gene expression could lead to the development of novel nucleic acid-based therapeutics for the treatment of cancers and other diseases. The data were presented by Michael V. Templin, Ph.D., Senior Vice President, Preclinical Development at Marina Biotech, Inc., at TIDES Oligonucleotide and Peptide® Research, Technology and Product Development May 22 - 25, 2011 in Boston, MA.
Carbon Sciences Inc. (OTCBB:CABN) reached up 13.85% in morning trading to $.074 with 650K shares traded. Carbon Sciences is developing a breakthrough technology to make gasoline from natural gas. They believe their technology will enable nations of the world to reduce their dependence on petroleum by cost effectively using natural gas to produce cleaner and greener liquid fuels for immediate use in the existing transportation infrastructure. Although found in abundant supply at affordable prices in the U.S. and throughout the world, natural gas cannot be used directly in cars, trucks, trains and planes without a massive overhaul of the existing transportation infrastructure. Innovating at the forefront of chemical engineering, Carbon Sciences is developing a highly scalable, clean-tech process to transform natural gas into liquid transportation fuels such as gasoline, diesel and jet fuel. The key to this cost-effective process is a breakthrough methane dry reforming catalyst that consumes carbon dioxide. Carbon Sciences Inc. (OTC.BB:CABN - News) announced yesterday afternoon initial test results of its dry reforming of methane technology in a commercial facility.
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