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Valence Technology (Nasdaq: VLNC) $1.03. Today announced that it expects revenue of approximately $13.5 to $14.0 million for its fiscal 2012 first quarter ended June 30, 2011. "Our first quarter revenue is projected to be above our May 25, 2011 guidance of $8.5 to $10.5 million, principally due to significant shipments to Smith Electric Vehicles. In addition, we continue to see a positive trend in orders from both existing and new customers. This includes dozens of customers in diverse markets worldwide,” commented president and chief executive officer Robert L. Kanode.
“We believe our products’ performance, safety, durability, cycle life, and energy density offer a compelling solution. With five years of on-the-road experience and a family of standard and custom products, Valence is well positioned in pursuing a broad base of emerging worldwide markets. In addition, due to our experience and vertical integration Valence can quickly scale as markets mature and grow,” continued Kanode.
Key Highlights include: In excess of 150 megawatt-hours of advanced energy storage solutions have been shipped since 2005. 54 unique customers during fiscal Q1 2012 including corporations in the United States, United Kingdom, France, Canada, Italy, the Netherlands, and Spain. Applications served include: metropolitan transit buses, sailboats, off-grid power trailers, postal scooters, commercial delivery vehicles, and Segway personal transporters.
What They Do: Valence Technology is a global leader in the development and manufacture of safe, long-life lithium iron magnesium phosphate advanced energy storage solutions and integrated command and control logic.
Sino Clean Energy (Nasdaq: SINO) $3.03. Today announced that it has entered into a non-binding, preliminary agreement to acquire 100% stake in Crown Energy Limited, an investment company registered in Hong Kong, which as its sole business holds a 60% stake in Foshan Nan Hai CWSF Co., Ltd. ("Foshan Nan Hai"). If after due diligence the Company decides to complete the acquisition, Sino Clean Energy will control a 60% stake in Foshan Nan Hai, a producer and distributor of CWSF in China.
Founded in 2003, Foshan Nan Hai has an installed capacity of 1.2 million metric tons and reserved capacity of 1 million metric tons and is widely recognized as the largest producer of CWSF in China. Located in Foshan City, Guangdong Province, where the local government promotes CWSF for energy conservation and carbon emissions reduction, Foshan Nan Hai supplies to the largest CWSF boiler in China and ships its CWSF output from its own 3,000-ton barge dock.
What They Do: The Company believes that Sino Clean Energy is the third largest producer of coal-water slurry fuel ("CWSF") by sales in China, according to data provided in Frost & Sullivan's 2010 Chinese CWSF market report.
Bionovo (Nasdaq: BNVI) $0.93. Today announced the publication of a study of the metabolic effects of its drug candidate, Bezielle, on cancer cells in the International Journal of Cancer.
"This study confirms and expands our earlier understanding of the mechanism of Bezielle cell killing effect," said Uwe Christians, MD, PhD, Professor, iC42 Integrated Solutions in Systems Biology for Clinical Research and Development, University of Colorado, Denver and Bionovo scientific advisory board member. "Bezielle demonstrates incredible selectivity in killing cancer cells while sparing normal cells. It does this by perturbing oxygen metabolism in the cells, from which normal cells can recover, while cancer cells cannot. Using a combined proteomic and metabolomic approach we discovered and confirmed which proteins and enzymes coordinate this selective activity in breast cancer."
The study describes how Bezielle induces selective death in cancer cells using a combined proteomic and metabolomic analysis. The study identified that Bezielle regulates important proteins controlling proliferation and death, such as Jab1, p27, p21 and nucleophosmin and prohibitin. It also regulates important proteins involved in oxidative stress such peroxiredoxin 2, 3 and 6 as well as thioredoxin reductase 1 and glutathione-S-transferase. This activity is seen in cancer cells but not in normal cells. The metabolomic analysis confirmed our observation that Bezielle inhibits energy production in the cells through inhibition of glycolysis, oxidative phosphorylation and lipid metabolism, and results in energetic collapse and therefore cancer cell death. The study concludes that the mechanism of action for Bezielle's cell killing effect is thereby confirmed by the concordance between the proteomic and metabolomic approaches. The paper, entitled, “Bezielle (BZL101)-induced oxidative stress damage followed by redistribution of metabolic fluxes in breast cancer cells.
What They Do: Bionovo is a pharmaceutical company focused on the discovery and development of safe and effective treatments for women's health and cancer, markets with significant unmet needs and billions in potential annual revenue.
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