CRXX 7/8/2009 3:13:10 AM
Afternoon Report - CRXX - CombinatoRx Publishes Research Demonstrating Improved Selectivity Through Synergistic Combinations - Sourced WhisperFromWallStreet.com
CombinatoRx, Incorporated
Afternoon Report - CRXX - CombinatoRx Publishes Research Demonstrating Improved Selectivity Through Synergistic Combinations - Sourced WhisperFromWallStreet.com
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CombinatoRx, Incorporated,CRXX
After Hours: 0.8090 Down 0.0210 (2.53%) 2:16pm ET
Today announced the advance online publication by CombinatoRx scientists of an extensive analysis of their discovery screening, scheduled to appear in the August issue of Nature Biotechnology. These new findings provide evidence that multi-target synergistic combinations may be more therapeutically specific than single agents.
By performing a comprehensive synergy analysis across pairs of assays covering six different disease areas and ~100,000 combinations, CombinatoRx scientists have empirically shown that synergistic combinations may yield greater therapeutic selectivity than single drugs. Therapeutic selectivity occurs when a treatment has more beneficial than toxic effect. Additional preclinical analysis by the authors on sample combinations shows that this selectivity results from coordinated context-specific multi-target activity.
The demonstrated increase in therapeutic selectivity by synergistic combinations has important implications for drug discovery, said Alexis Borisy, founder and scientific advisor to CombinatoRx. It expands how we define and think about drug targets, and shows how controlling complex biology is all about coordinated activity on multiple nodes in a disease network
This systematic exploration of combination therapy is made possible through the CombinatoRx combination high throughput screening (cHTS) technology, the potential of which has been demonstrated through notable pharmaceutical partnerships, such as our recent oncology alliance with Novartis, said Robert Forrester, Interim President and CEO of CombinatoRx. The CombinatoRx business strategy will continue to leverage our unique drug discovery platform.
About
CombinatoRx, Incorporated, a biopharmaceutical company, focuses on discovering, developing, and outlicensing synergistic combination pharmaceuticals. It develops novel therapeutics with multi-target mechanisms of action that are built from combinations of drugs that utilize novel biology to treat various conditions, including immuno-inflammatory diseases, cancer, metabolic diseases, inherited diseases, and other diseases. The company?s products include Synavive, a novel dissociated glucocorticoid product candidate to enhance the anti-inflammatory benefits of glucocorticoids, which completed phase II in rheumatoid arthritis, knee osteoarthritis, hand osteoarthritis, and biomarker study; CRx-401, an anti-diabetic agent, which is in phase IIa clinical study; and CRx-191, a topical synergistic combination drug candidate that has completed phase IIa clinical trials for psoriasis. Its products also include CRx-197, a novel topical anti-inflammatory product candidate that completed phase IIa clinical trials for the treatment of psoriasis, atopic dermatitis, and other inflammatory dermatoses; and CRx-170, an oral synergistic combination drug candidate, which completed phase IIa clinical trial for the potential treatment of chronic pain conditions. CombinatoRx, Incorporated has collaborations with Angiotech Pharmaceuticals, Inc.; Fovea Pharmaceuticals SA; Cystic Fibrosis Foundation Therapeutics Incorporated; CHDI, Inc.; Charley?s Fund and the Nash Avery Foundation; National Institutes of Allergy and Infectious Diseases; HenKan Pharmaceutical Company; Spinal Muscular Atrophy Foundation; Sirtris Pharmaceuticals, Inc.; and Novartis AG. The company was founded in 2000 and is based in Cambridge, Massachusetts.
Last Trade: 0.80
Day's Range: 0.79 - 0.85
52wk Range: 0.25 - 6.99
Volume: 42,300
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