Scottsdale 9/11/2012 10:00:00 PM
News / Finance

BioLineRX (BLRX) Reveals Preclinical Results Demonstrating Safety of Oral Treatment for Celiac Disease

QualityStocks would like to highlight BioLineRx Ltd. (NASDAQ: BLRX), a clinical stage biopharmaceutical development company which, together with its subsidiaries, engages in identifying, in-licensing, and developing therapeutic candidates. Its clinical therapeutic candidates under development consist of BL-1020 that is in Phase II/III clinical trials to improve cognitive function in schizophrenia patients; BL-1040, which is under pivotal CE-Mark registration trial for the prevention of cardiac remodeling following an acute myocardial infarction; BL-5010, which has completed Phase I/II clinical trials for non-surgical removal of skin lesions; BL-1021 that has completed Phase Ia clinical trial for the treatment of neuropathic pain or pain that results from damage to nerve fibers; and BL-7040, a synthetic oligonucleotide, which is in Phase II clinical trial for the treatment of inflammatory bowel disease.

In the company’s news yesterday,

BioLineRx announced that its orally available treatment for celiac disease, BL-7010, was found to be safe and well-tolerated and did not cause any adverse effects (even at high doses) in preclinical studies conducted to date. Additional studies showed that BL-7010 is specific to gliadins, the immunogenic peptides present in gluten that causes celiac disease and does not interact with non-related enzymes or vitamins in the digestive tract.

Additional efficacy studies of BL-7010 indicate it reduces digestion of wheat gluten, thereby decreasing its toxicity. BL-7010 also attenuates the immune response to gluten in rodents and prevents gluten-induced pathological damage to the small intestine. BL-7010 is not absorbed systemically which indicates its safety as a gluten neutralizing substance.

Professor Elena Verdu, who presented the data on BL-7010 to Better Life for Coeliacs 2012 Congress in Helsinki, said “BL-7010 may therefore be an effective adjuvant therapy [in addition to gluten-free diets] that will improve the quality of life for people with celiac disease throughout the world.”

If the findings are validated, it would certainly present an opportunity for BioLineRX to have a very successful treatment on its hands.

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