Austin, TX 12/10/2007 11:21:18 PM
Speak with other shareholders about: (Nasdaq: IMGN), (Nasdaq: TELK), (Nasdaq: MLNM), (Nasdaq: EPCT)
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ImmunoGen (Nasdaq: IMGN) Closed at $4.79. Today announced that encouraging clinical findings with the TAP compound, AVE9633, were reported today at the American Society of Hematology (ASH) 49th Annual Meeting and Exposition. AVE9633 demonstrated evidence of biological activity in multiple patients with relapsed/refractory acute myeloid leukemia (AML) and was found to be generally well tolerated.
Highly favorable preclinical findings also were reported for SAR3419, a TAP compound now in clinical testing for the treatment of non-Hodgkin's lymphoma and other B-cell malignancies.
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Telik (Nasdaq: TELK) Closed at $3.60. Today announced positive results from the multicenter Phase 1 dose-escalation study of TELINTRA (ezatiostat HCl) Tablets in myelodysplastic syndrome (MDS) that support the initiation of Phase 2 clinical trials. The data were reported at the 49th annual meeting of the American Society of Hematology in Atlanta.
The objectives of the trial were to evaluate the safety and pharmacokinetics of TELINTRA Tablets (also known as TLK199 Tablets), and obtain preliminary indications of efficacy (International Working Group, IWG, 2000 criteria). The trial enrolled 45 patients and included all WHO classifications of MDS. Patients received one of ten dose levels of TELINTRA Tablets taken daily for seven days followed by two weeks of follow-up. Patients could receive planned therapy up to six months (eight cycles) until MDS progression or unacceptable toxicity.
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Millennium Pharmaceuticals (Nasdaq: MLNM) Closed at $15.07. Today announced the presentation of results from an interim analysis of the first 256 patients evaluated in a multi-center, randomized Phase III clinical trial. This study compared VELCADE, thalidomide and dexamethasone (VcTD) to thalidomide and dexamethasone (TD) alone, currently the most commonly used U.S. regimen for patients with previously untreated multiple myeloma (MM). The trial was conducted by the Italian Myeloma Network (GIMEMA) cooperative group and selected for an oral presentation at the American Society of Hematology (ASH) 49th Annual Meeting in Atlanta, Ga., December 8- 11, 2007.
"This VELCADE based induction regimen achieved a fourfold increase in the complete remission rate. Complete remission is widely recognized as a predictor for long-term survival," said Professor Michele Cavo, M.D., Seragnoli Institute of Hematology, University of Bologna and Principal Investigator of the trial. "These exciting results demonstrated that adding VELCADE to the standard induction therapy prior to stem cell transplantation improves the response rate dramatically."
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EpiCept Corporation (Nasdaq: EPCT) Closed at $1.44. Today announced new clinical data that demonstrate a durable improvement in leukemia-free survival (LFS) over five years among Acute Myeloid Leukemia (AML) patients who receive post-consolidation immunotherapy with Ceplene(TM) (histamine dihydrochloride) in conjunction with low dose interleukin-2 (IL-2). These data were presented on December 9th at the 49th Annual Meeting of the American Society of Hematology (ASH) in Atlanta.
"This ASH meeting shows the tremendous progress ImmunoGen has made in recent years," commented Mitchel Sayare, Chairman and CEO. "In the past two days, impressive clinical findings were reported with two TAP compounds - IMGN901 and AVE9633 - in the treatment of multiple myeloma and acute myeloid leukemia, respectively, and highly favorable preclinical data were reported with a third TAP compound, SAR3419, for the treatment of lymphomas. In addition to the AVE9633 and SAR3419 findings presented, our collaborator sanofi-aventis also reported very encouraging clinical data on the naked antibody, AVE1642, that we initially developed and now is in broad development by them."
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